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In schizophrenia, working memory dysfunction is associated with altered expression of gamma-aminobutyric acid (GABA) A receptor α1 and α2 subunits in the dorsolateral prefrontal cortex (DLPFC). In rodents, cortical α subunit expression shifts from low α1 and high α2 to high α1 and low α2 during early postnatal development. Because these two α subunits confer different functional properties...
The goal of this study was to compare the extent of cognitive deficits between adolescents and adults early in the course of schizophrenia. A comprehensive neuropsychological battery was performed on 49 adolescents with childhood- or adolescent-onset schizophrenia, 139 adults with adult-onset schizophrenia, 32 healthy adolescent volunteers, and 240 healthy adult volunteers. Both patient groups...
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