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Chronic beryllium disease (CBD) results from exposure to the light-weight metal beryllium (Be). In vitro stimulation of bronchoalveolar lavage cells from CBD subjects causes the production of high levels of TNF-α, IFN-γ and IL-6. We tested the hypothesis that Be-stimulation might induce the production of TNF-α by macrophage cell lines. We observed that H36.12j cells (12j), a mouse hybrid macrophage...
We tested the hypothesis that beryllium (Be) could stimulate H36.12j cell (12j) TNF-α production by transcription factor-mediated pathways similar to those induced by either LPS- or IFN-γ stimulation. Unstimulated 12j cells produce constitutive levels of TNF-α (175+/-18 pg/ml, mean+/-SEM) detected by ELISA of culture supernatants after 24 h. Beryllium-stimulated (100 μM BeSO 4 ) 12j cell TNF-α...
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