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The authors describe an immunoassay for the determination of carcinoembryonic antigen (CEA) tumor markers by depositing a polydopamine-Pb(II) nanocomposite on the surface of a glassy carbon electrode. The nanocomposite acts as a redox system that displays a large specific surface and provides a strong current signal at −0.464 V (vs. Ag/AgCl). After the deposition of PDA-Pb2+ on glassy carbon electrode,...
We report herein an aptamer-based electrochemical biosensor for the quantitative determination of mucin 1 (MUC1), a glycoprotein expressed on most epithelial cell surfaces, based on the analyte-binding induced, global-scale conformational change of electrode-bound anti-MUC1 DNA aptamers. The modified electrode was readily prepared by directly immobilizing thiolated, single-stranded anti-MUC1 DNA aptamers...
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