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The circadian rhythm can be reset by a variety of substances. Prostaglandin J 2 (PGJ 2 ) is one such substance and resets the circadian rhythm in fibroblasts. In our current study, we examined the phase-dependent phase shift following PGJ 2 treatment using a real-time luciferase luminescence monitoring system. In the phase response curves, we observed 12h differences in the...
Endogenous rhythms of mammals are controlled by the clock located in the suprachiasmatic nucleus (SCN). The molecular mechanism of a clock involves transcription/translation-based feedback loops in which the expression of the so called “clock genes” is suppressed periodically by their protein products. Previous studies reported influence of the eye itself on the circadian oscillation of the SCN, apart...
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