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The roles played by glycine- and glutamate-mediated synaptic transmission in the generation of 5-hydroxytryptamine (5-HT)-induced rhythmic activity were examined in isolated spinal cord preparations from fetal rats. Bath application of 5-HT (0.1-30 μM) evoked rhythmic activity in lumbar ventral roots at and after E14.5. Bath application of strychnine (5 μM), a glycine-receptor antagonist, reduced...
The effects of bicuculline and strychnine on the activity and periaqueductal gray (PAG)-induced inhibition of rat dorsal horn neurons of the lumbar spinal cord were tested. Extracellular single unit recordings were from 36 dorsal horn neurons near a microdialysis fiber passed through the spinal cord for drug application. The GABA, receptor antagonist, bicuculline, was tested on 19 cells, whereas the...
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