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Myocardial infarction (MI) is one of the most common sudden-onset heart diseases. Early diagnosis and management of heart ischemia result in good prognosis. Early changes in the heart muscle activity after ischemia reflect in ST segment elevation on electrocardiogram (ECG) recordings. With the development of signal processing techniques and the portable devices, there is a need to develop a real-time...
Functional regeneration of infarcted myocardium is still a big challenge in the therapy of cardiovascular diseases. In the present study, PDGF-BB gene therapy was investigated after myocardial infarction (MI) in rats. We found that the infarct size of male rats treated with PBS(control) group was 0.436plusmn0.128, while it was 0.280plusmn0.055 in the male rats of PDGF-BB gene transferred group. The...
Four-dimensional (4D), or equivalently, 3D + time, analysis is useful for comprehensive assessment cardiac function, especially in the asymmetric left ventricle (LV) after myocardial infarction (MI). This paper presents a 4D-model-based method for ultrasound assessment of cardiac contractile function in mice. Echocardiographic image sequences were acquired at high frequency (30 MHz) from the hearts...
Understanding heart regeneration in a vertebrate model system is a highly relevant public health concern. Coronary heart disease is among the leading causes of disability and mortality worldwide. Injured human hearts caused by myocardial infarction (MI) results in decreased cardiac performance and eventually the development of heart failure. In contrast to mammals, zebrafish fully regenerate myocardium...
A model-based approach to noninvasively determine the location and size of the infarction scar is proposed, that in addition helps to estimate the risk of arrhythmias. The approach is based on the optimization of an electrophysiological heart model with an introduced infarction scar to fit the multichannel ECG measured on the surface of the patient's thorax. This model delivers the distributions of...
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