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In order to study the cytotoxicity effects of Nano-Fe3O4 Particles on HeLa Cells, 50μg/mL, 100μg/mL and 200μg/mL concentrations of Nano-Fe3O4 were exposed to HeLa cells, twelve hours later, single cell gel electrophoresis (SCGE) was used to detect HeLa cell DNA molecule damage, the content of the malondialdehyde (MDA) were determined by thiobarbiturie acid reactive substance method and the activity...
Iron oxide nanoparticles(Fe3O4 NPs) have recently received increasing interest in the biotechnology and life science. However, little is known about the nanoneurotoxicity of Fe3O4 NPs following exposure to neurons. This study was to elucidate the cytotoxicity and its mechanism of Fe3O4 NPs on PC12 cells line which derived from Rattus norvegicus pheochromocytoma. The cell viability was observed by...
We have previously reported the aqueous phase synthesis of mono-dispersive Fe3O4 nanoparticles with amine group surface modification. The nanoparticles exhibit satisfactory biocompatibility and significant MRI contrast in both in vitro and in vivo models. The magnetite nanoparticles could be manipulated by externally applied magnetic field. In this study, we have modified the naoparticle as an anti-cancer...
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