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Positron emission tomography (PET) with FDG or amyloid tracers is an important diagnostic tool, which also provides imaging biomarkers for patient selection in therapeutic trials in Alzheimer’s disease. PET is also a quantitative technique with the potential to measure disease severity and progression. Limitations in spatial resolution result in partial volume effects that can be minimized by correction...
Huge progress has been made in unraveling the mysteries of Alzheimer’s disease (AD), but we still do not understand the basic mechanisms that set off the cascade of pathological events. In May 2011, the National Institute on Aging–Alzheimer’s Association published new diagnostic guidelines, expected to have huge impact on AD research and clinical practice. However, the new guidelines are already criticized...
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