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Deep brain stimulation (DBS) injects a high frequency current that effectively disables the diseased basal ganglia (BG) circuit in Parkinson's disease (PD) patients, leading to a reversal of motor symptoms. Though therapeutic, high frequency stimulation consumes significant power forcing frequent surgical battery replacements and causing widespread influence into other brain areas which may lead to...
Neural systems encode representations of biological signals in the firing patterns of their spike trains. Spike trains are point process time-series and their codes are both dynamic and stochastic. Although the signal is often continuous, its representation in the nervous systems is as a high-dimensional point process time-series. Because neural spike trains are point processes, standard signal processing...
Tremor is one of the most disabling symptoms in patients with many movement disorders including Parkinson's disease (PD) and essential tremor (ET). Neural tremor manifests itself as a quasi-periodic fluctuation of the firing rate. We describe a frequency tracking method based on the extended Kalman smoother (EKS) to estimate the instantaneous tremor frequency (ITF) exhibited in binary spike trains...
Tremor is one of the most disabling symptoms in patients with many movement disorders including Parkinson's disease (PD) and essential tremor (ET). Neural tremor, which is measured by microelectrodes placed near nerve cells or obtained from brain cells during stereotactic neurosurgery, is due to the fluctuation of the firing rate of neurons. The frequency of this neural tremor varies over time and...
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