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Organs-on-chips systems are microfluidic three-dimensional miniature human organoid models designed to reproduce the key biological and physiological parameters of their in vivo counterparts. They have recently emerged as a viable platform for personalized medicine and drug screening. While a wide variety of human organ-on-a-chip models have been created, there are limited reports on the inclusion...
Lab on Chip devices have a great potential for medical applications as illustrated in three examples. First, a disposable, prefilled capillary electrophoresis chip for monitoring lithium in blood of manic depressive patients is discussed. In a second example, we present a simple chip for counting sperm cells in semen is presented that is used to determine male fertility. Finally, we present the realization...
A novel microphysiometry platform for dynamic cell culture monitoring in drug screening and cancer cell research is presented. The transparent system features an integrated cell cultivation area, microfluidics and (bio-)sensors for multiparametric metabolic monitoring, combined on a single glass chip. The parameters include glucose and lactate (amperometric biosensors), oxygen (amperometric), pH (potentiometric)...
We present the first implantable MEMS drug delivery device that includes an electrochemical bellows pump, refillable drug reservoir, and dual regulation valve. Multiple drug pump configurations were fabricated, assembled, and tested. Delivery of agents for cancer radiation reduction was demonstrated. In vivo chronic delivery of radiation sensitizing agents in the form of small interfering (siRNA)-gold...
pH micro sensors are nowadays often realized as potentiometric sensors with a metal oxide and a reference electrode. Many used or presented potentiometric pH micro sensors clearly lack in performance due to the used reference electrode. In this work, we describe a micro reference electrode with liquid-junction on chip, which is combined with iridium oxide as pH sensing electrode. The micro-reference...
Natural inter-neuronal communication is mediated primarily via neurotransmitter-gated ion channels. While most of the methods for neural interfacing have been based upon electrical stimulation, neurotransmitter-based approaches for the spatially and temporally controlled delivery of neurotransmitters are relatively new. Methods of neurotransmitter stimulation retinal prosthesis may provide new ways...
In vivo biomedical studies using animals can provide high similarity to the physiological conditions in humans. However, it is difficult to observe the molecular processes in the whole animals. On the contrary, in vitro studies could control the environmental factors in experiments but usually are difficult to reflect the complex physiological responses existing in vivo. In this paper, we report our...
Electrodes are fundamental to the reliable operation of a new generation of portable bio-analytical instruments based around microsystems technology. The importance of eliminating false positives and false negatives for these instruments is driving work around embedded test, condition monitoring and both diagnostics and prognostics. This paper proposes two solutions for detecting degradation in electrodes...
The fabrication and characterization of a fully integrated capillary electrophoresis (CE)-based microfluidic device with integrated carbon sensing electrode is described in this study. A combination of microfabrication protocols were employed for fabricating the hybrid polydimethyl siloxane (PDMS)/glass microfluidic device including chemical wet etching, soft lithography, and micromolding techniques...
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