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The major histocompatibility complex system is the most polymorphic gene cluster of the mammal genome. In humans, this is a genomic locus known as the human leukocyte antigen (HLA) system. The HLA encodes mostly immune-associated proteins whose main effect is the presentation of antigens to the immune cells. Thus, it is clear that it is essential for to the proper function of the immune response against...
Immune thrombocytopenic purpura (ITP) is an autoimmune condition characterized by low platelet count and mucocutaneous bleeding. Antibody‐coated platelets undergo reticuloendothelial phagocytosis, resulting in reduced platelet survival. Furthermore, CD8+ and CD4+ T cell‐mediated responses are both implicated in the pathogenesis of autoimmune thrombocytopenia. The onset can be primary or secondary...
Guillain–Barré syndrome (GBS) is a rare autoimmune disorder, the incidence of which is estimated to be 0.6–4/100,000 person/year worldwide. Often, GBS occurs a few days or weeks after the patient has had symptoms of a respiratory or gastrointestinal microbial infection. The disorder is sub-acute developing over the course of hours or days up to 3 to 4 weeks. About a third of all cases of Guillain–Barré...
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