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Craniofacial and ocular morphogenesis require proper regulation of cranial neural crest migration, proliferation, survival and differentiation. Although alterations in maternal thyroid hormone (TH) are associated with congenital craniofacial anomalies, the role of TH on the neural crest has not been previously described. Using zebrafish, we demonstrate that pharmacologic and genetic alterations in...
Environmental cues are known to be important in the migration, survival, and differentiation of neural crest cells and their derivatives. Retinoic acid (RA) can increase the number of adrenergic cells that develop in neural crest cultures in a dose dependent manner. These results with RA prompted us to investigate the effects of other retinoids and other related compounds on neural crest cultures...
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