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Aspirin (ASA), as a multifunctional drug has been used as a hypoglycaemic agent in the treatment of diabetes and severe hyperglycaemia and has been established as a secondary strategy which may prevent many cardiovascular events. In this study we investigated high dose (100 mg/kg b.w./i.p) and time-dependent (2, 7 and 14 days) effects of ASA on the heart key enzymes and substrates from glycogen/glucose...
To investigate the protective effect of Trigonella foenum greacum.L Saponin (TFGs) on myocardial tissue of rats with experimental diabetes mellitus induced by streptozotocin(STZ) and its mechanism. A total of 42 Wistar rats were enrolled in the study, 10 of them were set as normal controls, others were injected STZ to establish the animal model of diabetes mellitus, and then they were randomly divided...
In order to contribute to biomedical text extraction and mining in the field of modern research of pattern in traditional Chinese medicine (TCM), MeSH mining method was used in this study. Based on “Different diseases with same pattern” theory in TCM, rheumatoid arthritis, coronary heart disease and diabetes mellitus were selected to explore the potential biological network shared in these three diseases...
The permeability in the intact and diabetic rat coronary circulation after administration of secretin (3.0 μmol/kg i.v.), an inhibitor of NOS (nitric oxide synthase), and l-NAME (N G -nitro-l-arginine-methyl ester hydrochloride) (1 mg/kg i.v.), and both substances given together, were studied. To measure protein extravasation Evans blue dye was used as a marker of vascular permeability. The...
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