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Photodynamic therapy (PDT) uses photosensitizers, light and molecular oxygen to generate cytotoxic reactive oxygen species. Its effectiveness is limited to <1 cm due to the limited penetration depth of light. The present study compares the PDT effectivity of the photosensitizer verteporfin (VP) conjugated to gold nanoparticles (AuNPs) (a) by using deeply penetrating X-rays administered in standard...
Hypocrellins, perylenequinonoid pigments isolated from Hypocrella bambusae, are known photodynamic agents. They exhibit several advantages over the other photosensitizers, such as ready preparation, easy purification, low aggregation tendency, high singlet oxygen generation quantum yield and rapid metabolism in vivo. However, hypocrellins do not exhibit absorption at wavelengths longer than 600 nm,...
Objective: Study the influence of Hematoporphyrin Monomethyl Ether (HMME) concentration in blood vessel in a rather short time on photodynamic therapy (PDT) microvascular effect by mathematical modeling and animal experiment. Methods: The yields of singlet oxygen in blood vessel in a short time in different animal were simulated by mathematical model, and the yields of singlet oxygen in Leghorn Cocks...
Active oxygen series, especially singlet oxygen (1O2), often need to be detected, such as detection of Photodynamic therapy (PDT), seed vigour and plant stress, and so on. Chemiluminescence(CL) is high sensitive to detect active oxygen and can be easily realized with a conventional optical detector. It is utilized in many fields. Fluoresceinyl Cypridina Luciferin Analog (FCLA) is a high sensitive...
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