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In the present study, we investigated the effect of immediate post-training bilateral infusion of spermidine, a polyamine agonist, into the amygdala on inhibitory avoidance learning of rats. Bilateral microinjection of spermidine (0.02-20 nmol) caused an increase in test step-down latencies at high concentrations. Administration of arcaine (0.002-0.2 nmol), an antagonist of the NMDA receptor polyamine...
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