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Being elderly is a risk factor for delayed wound healing. In aged skin, epidermal turnover is decreased by about 50%. This is accompanied by reductions in vascularization, granulation tissue, collagen, elastin, mast cells and fibroblasts. Age-related changes occur which impact all phases of healing. In general, the elderly have increased rates of infection and wound dehiscence, decreases in wound...
Graves' ophthalmopathy (GO) is an extra-thyroidal complication of Graves' disease (GD; Graves' hyperthyroidism) characterized by orbital tissue inflammation, expansion, remodeling and fibrosis. Although the initiating trigger of GO is still indistinct, excessive orbital fibroblast activity is at the heart of its pathogenesis. Orbital fibroblasts are activated by cellular interactions with immune cells...
Several factors, including mineralocorticoids, have been implicated in the renal damage associated with hypertension. Peroxisome proliferator activated receptor gamma (PPAR-) agonists improve renal damage associated with different pathologies. Therefore, our hypothesis was that mineralocorticoid receptor blockade ameliorates renal damage associated with hypertension and that this improvement may be...
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