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Computational tools are indispensable in the genetic engineering today. This research employs computational analysis on microRNAs which are targeting at the PTEN gene. This study aims to analyze the implication of microRNAs in the expression of PTEN which is leading to tumorigenesis. The analysis of microRNAs sheds light on the regulatory mechanism of PTEN in cancer development.
RNA regulation has been increasingly recognized as a potential and perhaps overlooked genetics of higher organisms. Noncoding RNAs (ncRNA) may play various catalytic and regulatory roles in the genetic operating system. Recent studies using comparative genomics and molecular genetics show evidence of the presence of varied ncRNAs. Unlike protein coding genes, there is a lack of comparable information...
MicroRNAs (miRNAs) reported previously from Arabidopsis. thaliana and other seven plant species, by both experimental validation and prediction, were used to identify potential miRNAs in Saccharum officinarum which is an important food and bio-energy crop. A microfluidic microarray was developed for detecting plant miRNAs and used for the first experimental analyzing the mature miRNAs and miRNAs*...
MicroRNAs (miRNAs) are small noncoding RNA gene products. It is important in biology and biomedicine. The miRNA is closely related to human disease, in particular, such as cancer and tumor. We develop an information system for miRNA, which integrates a variety of existing miRNA information system on the market. The system offers as much information as possible; meanwhile it costs as less time as possible...
Coding and non-coding gene prediction is still a challenge. Diverse computer-based tools have been created to screen sequences using elaborate strategies for gene prediction. Many of these implement various statistical tests to measure the plausibility of the prediction but until now, a comprehensive negative control did not exist. We developed an algorithm that generates sequences with characteristics...
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