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Microtubules, microfilaments, and neurofilaments are cytoskeletal elements that affect cell morphology, cellular processes, and mechanical structures in neural cells. The objective of the current study was to investigate the contribution of each type of cytoskeletal element to the mechanical properties of axons of dorsal root and sympathetic ganglia cells in chick embryos. Microtubules, microfilaments,...
Randomly cross-linked fiber networks are the building blocks of many biological systems such as cytoskeleton and tissue scaffolds. Here, we study the elastic properties of these networks at various length scales by mapping their elasticity into heterogeneous two-dimensional continuum media. The inhomogeneous elastic properties of the continuum domain are obtained from a minimization technique. It...
The spinal shock-absorbing disc needs to have the flexibility to enable the spine to bend and twist. At the same time under loading, its lateral and axial deformations have to be contained, so that it does not herniate and impinge on the spinal-chord. The disc is composed of a fluid-like nucleus pulposus (NP) contained within an annulus. Hence when the disc is loaded, the NP gets pressurized and stresses...
A microrobotic force sensing system is used to characterize the mechanical properties of the chorion of zebrafish embryos and quantitate the mechanical property differences of the chorion at different developmental stages. Quantitative relationships between applied forces and chorion structural deformations are established for various developmental stages. The measured penetration forces for puncturing...
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