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Objectives This study was conducted to evaluate the potential role of CASP8 genetic polymorphisms in the etiology of breast cancer in a case–control study, Korea. Methods Incident breast cancer cases confirmed histologically (n = 1,599) were recruited from two hospitals in Seoul during 2001–2005. Control subjects (n = 1,536) were selected from the Health Examinee Cohort from Seoul and Gyeonggi...
Background Recent evidence suggests a role for progesterone in breast cancer development and tumorigenesis. Progesterone exerts its effect on target cells by interacting with its receptor; thus, genetic variations, which might cause alterations in the biological function in the progesterone receptor (PGR), can potentially contribute to an individual's susceptibility to breast cancer. It has been reported...
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