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Indomethacin at a concentration (1O -4 M) which depressed the effect on O 2- generation by fMet-Leu-Phe, markedly enhanced O 2- , generation by both 1-oleoyl-2-acetylglycerol and the calcium ionophore, A23187. These results are explicable in terms of the hypothesis that synergism between cytosolic calcium and protein kinase C is involved in signal transduction...
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