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Cardiac hypertrophy in humans is associated with a decrease in myocardial fatty acid β-oxidation (FAO) and accompanying alterations in metabolic gene expression. Flux through the cardiac FAO pathway, which is the principal source of energy production in the adult mammalian heart, is tightly controlled in accordance with energy demands. In rodents, the FAO pathway is under control of a nuclear peroxisome...
1. The effects of the ACE inhibitor enalapril were studied in rats with cardiac hypertrophy induced by abdominal aortic constriction. This experimental model has shown that pump failure can be evidenced only during increased workload.2. Under basal conditions, enalapril at 1-3 mg/kg induced a significant reduction in blood pressure. During the acute volume loading or the increase in afterload due...
Ubiquitin; there is no doubt that ubiquitin is a lucky protein. It is lucky in many ways: lucky for scientific progress, lucky for biomedical scientists and lucky for life! If you have not already done so, why don't you get lucky and look for a role for ubiquitin in your experimental system. As Avram Hershko has said there is plently to go around ! (Previousy quoted by Mayer et al. .)
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