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Brain-derived neurotrophic factor (BDNF) is involved in the formation of dependence on opiates. BDNF mRNA expression is altered during opiate dependence; however, the biological basis of this phenomenon has been insufficiently studied. At the posttranscriptional level, microRNAs may potentially regulate BDNF expression. Short non-coding microRNAs bind in a complementary manner, mostly to the 3'-noncoding...
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