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In this paper we attempt to present a multilayered structure biosensor. A grating-based surface plasmon resonance (SPR) biosensor is considered as a structure that offers enhancement of the sensitivity in comparison with conventional biosensors. The sensitivity improvement caused by the presence of grating is discussed through monitoring of the biomolecular interactions and following that refractive...
This paper presents a novel method to fabricate gold nano-particle (NP) coated PDMS waveguides for localized surface plasmon resonance (LSPR) detection of biosamples. In the presented method, PDMS optical waveguide is firstly cast in a Teflon tubing to form a cylindrical leaky waveguide structure. The de-molded PDMS optical waveguide is then modified with PDDA molecules and deposited a layer of 13...
We report on a novel approach to identify genetic variations based on the detection of specific polymerase-chain-reaction products by surface plasmon resonance. We use a recently developed, home-made spectrometer which exploits chips with integrated optics and microfluidics. The gold film at the chip surface is locally functionalized with single-stranded, thiol-modified probe DNA by applying a nanoliter...
A wavelength interrogation-based surface plasmon resonance (SPR) biosensor has been investigated for a detection of avian influenza DNA (AI-DNA). The hybridization reaction between AI-DNA and the immobilized oligonucleotide probe on a gold surface was monitored. The results showed that SPR biosensor can provide a linear detection suitable for quantification of AI-DNA hybridization as well as a large...
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