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Electro spun nanofibers of blends of natural and synthetic biodegradable polymers have gained great attention due to their extensive biomedical applications in different fields such as tissue engineering, implant coating and drug delivery.
Due to the special structures of cell membrane, good internalization is one of major concerns on using large nanospheres as carriers for labeling and treatment of cancer. We herein report fluorescent gelatin nanosphers (GNs) coated with CdSe/ZnS quantum dots (QDs) to form a viable vehicle for theranostic applications. Anti-human immunoglobulin G Fab formation, anti-IgG Fab, is bioconjugated on to...
In a prior contribution, we described a semi-automated system that allowed a user to quantify the relative abundance of fluorescently labeled membrane proteins in confocal microscopy images. Here, we describe a step change in assay automation, enabled by explicitly casting the problem in terms of mathematical graphs. This permitted to include extensive and relevant image information in the tracing...
While basic principles of microtubule organization are well understood, much remains to be learned about the extent and significance of variation in that organization among cell types and conditions. Large numbers of images of microtubule distributions for many cell types can be readily obtained by high throughput fluorescence microscopy but direct estimation of the parameters underlying the organization...
The purpose of this article was to observe interaction between drug and cancer cell with fluorescence probes and molecular imaging technology. In order to study the effect of cell growth and apoptosis morphology of Human gastric adenocarcinoma SGC-7901 induced by n-butanol extract from Capparis spionosa L. (CSBE), laser scanning microscopy was employed to observe apoptosis imaging. In addition, the...
The purpose of this article was to observe interaction between drug and cancer cell with fluorescence probes and molecular imaging technology. In order to study the effect of cell growth and apoptosis morphology of Human gastric adenocarcinoma SGC-7901 induced by n-butanol extract from Capparis spionosa L. (CSBE), laser scanning microscopy was employed to observe apoptosis imaging. In addition, the...
The distribution, directionality and motility of the actin fibers control cell shape, affect cell function and are different in cancer versus normal cells. Quantification of actin structural changes is important for further understanding differences between cell types and for elucidation of the effects and dynamics of drug interactions. We have developed an image analysis framework for quantifying...
In this paper, we propose a stochastic simulation to model and analyze cellular signal transduction. The high number of objects in a simulation requires advanced visualization techniques: first to handle the large data sets, second to support the human perception in the crowded environment, and third to provide an interactive exploration tool. To adjust the state of the cell to an external signal,...
A transparent artificial cornea derived from biological material is the ultimate goal of corneal research. Attempts at artificial corneal constructs produced from synthetic polymers have proved unsuccessful due to lack of biocompatibility and ability to integrate into the tissue. We have designed a corneal model derived from collagenous biological materials that has several advantages: it has low...
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