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Aims: The aim of this study was to investigate the protective effects of FAC in hepatic fibrosis (HF) and the underlined mechanism. Methods: Using KM mice subjected to CCl4-induced HF. At the end of the experiment, the tissues of liver were removed for histopathological examination and SOD, MDA, HYP assays. The expressions of PPARγ were detected by immunohistochemistry. Result: we found that administration...
Idiosyncratic drug hepatotoxicity is a hepatotoxicity subset that occurs in a very small fraction of human patients, is poorly predicted by standard preclinical models and in clinical trials, and frequently leads to postapproval drug failure. Animal models utilizing bacterial LPS co-administration to induce an inflammatory background and hepatocyte cell culture models utilizing cytokine mix cotreatment...
Hepatitis B virus (HBV) infected people are at high risk of death from cirrhosis of the liver and liver cancer. To overcome the drug-resistant challenge of current anti-HBV compounds, substances blocking host support proteins in HBV infection are becoming increasingly important. Comprehensive HBV-human interactome map, which describe gene-level interactions of HBV proteins with human proteins, may...
To illustrate the possible function of genotoxicity of BBP on DNA, this study took mice livers as experimental materials to detect the levels of DNA-protein crosslinks (DPC), the activity of surperoxide dismutase (SOD), and the contents of malondialdehyde (MDA) with intraperitioneal injection of different doses of BBP for two consecutive 14 days. DPC levels in hepatic cells showed a dose-dependent...
This study was designed to develop and evaluate a chitosan-collagen-soybean phosphatidylcholine (SPC) complex film impregnated with mitomycin C (MMC)-PLA- nanoparticles for treatment of hepatocellular carcinoma in mice. MMC-PLA-nanoparticles were prepared by a reverse micelle-solvent evaporation method. PLA-MMC-nanoparticles were dispersed throughout the film. SEM, ATR-FTIR were used to character...
We investigate the protective effects of VnA against lung injury induced by hepatic ischemia/reperfusion and its possible mechanism in rats. Forty male Wistar rats were randomly divided into control group, hepatic ischemia reperfusion group, low and high dose VnA pretreatment group. Hepatic I/R reduce lung injury characterized by histological changes and lung water content increasing. VnA pretreatment...
The protective effect of oxyresveratrol from Ramulus mori against alloxan induced liver damage in mice was examined. In this study, the activities of serum aspartate aminotransferase, serum alanine aminotransferase and superoxide dismutase, catalase and the contents of malonyldialdehyde and reduced glutathione in liver were measured. Mice were divided into five groups as control, model control (only...
AFP-producing gastric carcinoma(APGC) are known to have a poorer prognosis and to show a higher incidence of liver metastasis than ordinary gastric carcinoma. Therefore, surgical resection, chemotherapy or radiotherapy is usually not satisfactory. In recent years, effects of arsenic trioxide (As2O3) on cell proliferation and induced apoptosis of solid tumors have been widely studied, while little...
To determine the effect of osthole on protein expression of PPARalpha/gamma and related target molecules such as CYP7A and DGAT in the liver of hyperlipidemic fatty liver (HFL) rats, and to investigate the possible mechanism of treating HFL. HFL rat model was established by feeding the Sprague-Dawley rats with fat milk for 6 weeks. The experimental rats were then treated with 5-20 mg/kg osthole for...
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