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The key technology of image compression is that image data is transformed, the transformed data is quantized and the quantized data is entropy coding. Using wavelet image compression is a common method of image compression, and this paper uses wavelet transform, multi-resolution analysis and quantization and coding of different scale wavelet coefficients to achieve image compression. And at the same...
The evolution of drug resistance in malaria continues to be a widespread concern. Many of these drugs target key proteins such as dihydrofolate reductase (DHFR). However in malaria, the structural plasticity of DHFR allows it to maintain its active site and catalytic activity, while resisting drug binding. One way to better understand this process is through the appreciation of DHFR structural evolution...
In this overview we will explore how current terahertz (THz) and sub-THz experimental systems are being used in a variety of ways to visualise and indeed, controllably excite biochemical processes. For example, a contributing cause to disease is known to be due to mis-folding proteins. But how proteins fold in order to perform a biological task is a deep mystery. The difficulty in understanding what...
AMP-activated protein kinase (AMPK) is a metabolite- sensed protein kinase in various eukaryotes. The activated AMPK regulates important proteins which cause diabetes, obesity, metabolic aberrant, and also breast cancer. In this study, the yeast AMPK structure was used as a template to model the human AMPK structure. By homology modeling, the reliable AMPK structure was built, and the active binding...
HER2 over-expression associates with many cancer symptoms, and the HER2 protein kinase was regarded as the target for cancer treatment. To develop the novel potent leads, homology modeling and structure-based design were employed to this research. Three clinical trail drugs and traditional Chinese medicine (TCM) database were employed to perform the docking. The top 7 compounds from database with...
Molecular docking technology is an important tool in computer-aided drug discovery and structure prediction for the protein-ligand complex. In this work, based on the analysis of the algorithm of the widely used the docking program AutoDock, we proposed a hybrid parallel method using the message passing interface (MPI) library. The modified programs were applied to dock the small molecule XK263 to...
Heat shock protein 90 (HSP90) regulates the correct folding of nascent protein in tumor cells. Through the ATPase domain of HSP90, inhibition of its activity is a manipulation for anticancer treatment. Two series of anticancer compounds, flavonoids and YC-1 derivatives, were employed in this study. The reference ligand in the docking simulation showed the significant RMSD of 0.87 with respect to the...
About 40% of all marketed drugs have the so-called G-protein coupled receptors (GPCRs) as their target protein. There exist more than 800 different GPCRs in humans, of which at least 300 GPCRs are believed to be druggable. Yet, for only two GPCRs there are three-dimensional (3D) protein crystal structures available and consequently little is known about the molecular interactions between pharmacologically...
We have employed bulk acoustic wave and surface acoustic wave devices for the sensitive and specific detection of biological agents in complex liquid media. We have produced a robotic liquid delivery system coupled to a multi-layer microfluidic manifold that delivers liquids in a controlled manner to pairs of resonant acoustic sensors in a dasiaUSBpsila type docking station. These resonators were...
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