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Abdominal aortic aneurysm is a cardiovascular disease which occurs due to an abnormal weakening of the aorta wall. This failure in aortic wall causes the inner layer to be ruptured because of excessive blood pressure. Consequently, the blood flows into the space between lumen and epithelial, hence a thrombus is generated. On the other hand, excessive growth in the aorta diameter can lead to death...
Atherosclerosis is the most prevalent cardiovascular disease which affects millions of people globally each year. The development of atheroma is directly connected to the interaction of blood flow with the arterial wall. Therefore, the modeling of this interaction is of critical importance for the study of arterial blood flow mechanics and the progression of atherosclerosis. In this study, we use...
Wave speed is one of the key factors describing wave propagation in arteries. Local wave speed is directly related to the arterial wall properties. With aging, arterial wave speed increases due to the stiffening of arterial wall, and also related to arterial disease. Several methods have been proposed to obtain wave speed in arteries, such as foot-to-foot and PU-loop methods. A technique developed...
The goal of the present study was to develop a physiologically realistic 3D computational fluid dynamics (CFD) model of the left coronary artery under normal and disease conditions to estimate blood flow induced shear stress, and then use the computed shear stress to stimulate vascular endothelial cells in vitro. A 3D geometry of the left coronary artery was built in ProE and the CFD analysis of the...
We inspected the relationship between cardiovascular disease and clinical pulse wave data. The pulse wave data were collected from the Department of Cardiology at Shandong Provincial Hospital by infrared light pulse wave sensor. Based on the risk factors, Stiffness Index (SI) and Cardiac Output (CO) are utilized as the characteristics to detect cardiovascular disease. The results show a close relationship...
Atherosclerosis, the precursor to acute events such as myocardial infarction and stroke, is a focal inflammatory disease that is influenced by local hemodynamic forces such as wall shear stress (WSS). Phase contrast (PC) MRI is an established method that encodes blood velocity into the phase of an image. A requisite step for the calculation of WSS from PC-MRI data is delineation of the vasculature...
Cardiovascular disease is the leading cause of morbidity and mortality in the USA. Disease management programs, while successful, are intensive and expensive. Follow-up is often inadequate, incomplete, and inconsistent. To address these problems, we developed an Internet- Telemedicine system. Patients send/receive data to/from their care provider via the Internet. The system optimizes function and...
The vascular geometry may play an important role in the development of atherosclerosis by modulating the local hemodynamics and mechanical stresses of the vessel wall. The mouse is now the most popular animal model to study cardiovascular disease. Here, we present a method to characterize the 3-D geometry of mouse aortic arches by casting and light stereo-microscopic imaging. After calibration of...
The vascular geometry may play an important role in the development of atherosclerosis by modulating the local hemodynamics and mechanical stresses of the vessel wall. The mouse is now the most popular animal model to study cardiovascular disease. Here, we present a method to characterize the 3-D geometry of mouse aortic arches by casting and light stereo-microscopic imaging. After calibration of...
Analysis of elastic laminae provides vital information on both the gross and fine structures of the arterial wall, which is vital to assess issues such as mechanical damage caused by cardiovascular disease or clinical treatment. For example, the distribution of thickness, and distance between them, of the elastic laminae within the aorta can provide important clues on how hypertension affects aortic...
Nowadays, circulatory support has become a common practice in medicine and a standard in the treatments of cardio vascular disease (CVD). A new pneumatic ventricular assist device (VAD) has been developed in Mexico City. This paper shows the first results of acute in-vivo trials, intended to verify the new system for providing physiological flows and pressures. Two VADs were implanted to as right...
Color flow imaging plays a major role in the diagnosis of many vascular diseases, especially cardiovascular disease. The imaging quality is highly influenced by the clutter originating from the vascular wall, stationary and slowly moving tissues and relative motion between the probe held by doctor and the blood flow. The clutter rejection filter in front of the mean frequency estimator will restrict...
This report is to investigate the correlation between common carotid blood flow (CCBF) properties and the risk factors for cardiovascular disease. The measurement system was designed for simultaneously monitoring of CCBF and electrocardiogram (ECG) in order to get more valid information for detection and diagnosis of cardiovascular disease. In our study, blood flow velocimeter was developed to measure...
The risk for cardiovascular disease is significantly high in diabetes mellitus. Experimental evidence suggests that oxidative stress plays a dominant role in the pathogenesis of diabetes mellitus. Carvedilol, a non-selective beta-adrenoceptor and selective alpha1-adrenoceptor blocker, also has antioxidant and free radical scavenger properties. In the present study the effect of carvedilol on the antioxidative...
Heart failure has been identified as a serious international problem, in particular for aging groups, posing both an increasing number of patients on waiting lists in countries susceptible with Medicare systems and increasing financial burdens. It may be imperative to develop a marker that can identify such problems at an early stage. It is believed that certain proteins have crucial roles in early...
Our purpose of the study is to measure the blood flow in the carotid artery during physical exercises. We have developed the blood flow velocimeter during physical exercises by using the non-invasive Doppler ultrasound method. We used it and measured blood flow in the carotid artery in which using a cycle ergometer and had two exercise tests in this report. The protocol exercise with transient response...
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