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For almost 40 years, difluoromethylene phosphonates have proven to be versatile molecular tools in biochemical studies owing to their close resemblance to naturally occurring phosphates and phosphonates. As bioisosteric, non‐hydrolyzable analogs of these essential molecules, difluoromethylene phosphonates can target the critical parts of the cellular machinery and therefore exhibit a diverse spectrum...
The front cover picture, designed by Michael Shevchuk, illustrates difluoromethylene phosphonates as bioisosteric, non‐hydrolyzable analogs of natural phosphates, reflecting on their prominence as molecular tools to study intricate phosphate biochemistry and beyond. The review comprehensively summarizes the recent synthetic advances in the chemistry of difluoromethylene phosphonates, such as visible...