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Accurate detection of the human metaphase chromosome centromere is an important step in many chromosome analysis and medical diagnosis algorithms. The centromere location can be utilized to derive information such as the chromosome type, polarity assignment, etc. Methods available in the literature yield unreliable results mainly due to high variability of morphology in metaphase chromosomes and boundary...
This paper proposes a novel external force for active contours, called adaptive diffusion flow (ADF). We reconsider the generative mechanism of gradient vector flow (GVF) diffusion process from the perspective of image restoration, and exploit a harmonic hyper surface minimal function to substitute smoothness energy term of GVF for alleviating the possible leakage problem. Meanwhile, a ∞- laplacian...
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