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Turn off the lights! A universal nanoquencher that quenches a broad range of visible to near‐infrared dyes by using a series of dark quenchers incorporated into a cell‐permeable mesoporous silica nanoparticle has been developed. In combination with dye‐labeled substrates, this nanoquencher boosts multiple fluorescence signals upon specific proteolysis, which allows real‐time imaging of proteolytic...
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