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Opioid analgesia involves suppression of neuronal activity in central sensory pathways. We show that the classic opioid morphine reduces spinal neuronal spontaneous and evoked activity after induction of neuropathy by chronic constriction injury of the sciatic nerve in rats. The minimal effective dose of morphine was 0.3mg/kg for most response parameters tested. Morphine sensitivity of spinal cord...
The present study was undertaken to clarify how spinal muscarinic receptors can be involved in the antinociceptive effects induced by morphine in thermal stimulation. The morphine-induced antinociceptive effects (26.6μmol/kg, s.c.) was inhibited by an intrathecal (i.t.) injection of the muscarinic antagonist (M) atropine and the M 1 /M 4 antagonist pirenzepine in a dose-dependent manner...
Ziconotide (SNX-111), a selective blocker of neuronal N-type voltage-sensitive calcium channels, is antinociceptive when it is administered intrathecally. It is currently under clinical investigation for the treatment of malignant and non-malignant pain syndromes. The present study was undertaken to compare and contrast antinociceptive properties of ziconotide, morphine and clonidine in a rat model...
There has been conflicting evidence concerning the role of descending bulbospinal influences on pain and opioid analgesia in the formalin test. We examined the effect of lesions of the dorsolateral funiculus (DLF) on dose-effect relations for formalin and morphine in the formalin test. Experiment 1 showed that DLF lesions reduced the effect of 5 mg/kg morphine on pain in the tail-flick test, and eliminated...
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