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31 Phosphorous magnetic resonance spectroscopy (2D chemical shift imaging, CSI) allows multiregional study of membrane phospholipids and high-energy phosphates in vivo. Increased membrane lipid turnover and impaired energy supply have repeatedly been shown in first-episode schizophrenia patients, and might be a target of drug actions other than dopamine receptors. Here, we explored differential...
Plusieurs dizaines d’années de recherches consacrées à l’étude du support biologique des maladies mentales ont permis de faire des progrès considérables dans la connaissance du fonctionnement du cerveau et de soulever des hypothèses très intéressantes concernant la physiopathologie de ces maladies. Cet article retrace succinctement l’historique des observations biochimiques qui ont conduit aux hypothèses...
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