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The effect of nitric oxide (NO) on the oxidative burst was analyzed in purified murine microglial cells in vitro. The generation of reactive oxygen derivatives was monitored with the use of luminol-dependent chemiluminescence. After inducing the endogenous NO production with interleukin 1β (IL-1β) and interferon-γ (IFN-γ) the superoxide anion release was significantly reduced, which was reversed by...
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