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In asymptomatic patients with type 2 diabetes (T2D), the prevalence of silent myocardial infarction on routine electrocardiograms is about 4% while for silent myocardial ischemia it is 20–30%. Some studies showed that silent myocardial infarction is associated with an increased risk of incident heart failure (HF), whereas no prospective study has ever reported such a risk in patients with silent myocardial...
Background Health-related quality of life (HRQL) is an increasingly well-recognized measure of health outcome in cardiology. We examined HRQL as a predictor of unplanned rehospitalization for cardiac reasons in patients after coronary revascularization over a period of 3 years. Patients and methods Out of 791 patients enrolled in the study, 743 completed the MacNew HRQL questionnaire after coronary...
Cornerstones in the treatment of coronary artery disease (CAD) are medical therapy and coronary revascularization. In acute settings (ST-elevation myocardial infarction and non-ST-elevation myocardial infarction), percutaneous coronary intervention (PCI) has proven to improve prognosis. The optimal treatment of stable CAD is subject to great controversy. By using fractional flow reserve to guide PCI,...
The question of how to optimally manage coronary artery disease (CAD) has been a challenge for the cardiology community. The results of early, large randomized clinical trials (RCTs) comparing strategies of medical therapy alone versus revascularization plus medical therapy in patients with stable CAD suggested a survival advantage for a revascularization strategy in the setting of more advanced,...
Growth differentiation factor-(GDF-)15 is a stress-responsive cytokine that is emerging as a biomarker of cardiac and vascular dysfunction and disease. Elevated circulating levels of GDF-15 identify high-risk individuals across the cardiovascular continuum, from stable coronary artery disease to acute coronary syndrome and heart failure. The association of GDF-15 with outcome in these conditions...
Die Endotheldysfunktion gilt als Prädiktor zukünftiger kardiovaskulärer Ereignisse und geht einer Makroangiopathie der Koronararterien zeitlich voraus. Bei Patienten mit koronarer Herzkrankheit verbessert aerobes körperliches Ausdauertraining die myokardiale Perfusion aufgrund einer partiellen Korrektur der Endotheldysfunktion, vermindert damit die Angina-pectoris-Symptomatik und reduziert ebenfalls...
Once considered to fulfill no other purpose than that of a physical barrier between blood and tissue, the multifunctional nature of the endothelium was discovered in the later half of the 20th century. In cardiology, the dysfunctional nature of the endothelium has received even more attention, initially mainly within the research community but later also in the clinical community, serving as a prime...
Die Endotheldysfunktion wurde als Prädiktor zukünftiger kardiovaskulärer Ereignisse identifiziert und geht einer signifikanten Makroangiopathie der Koronararterien zeitlich voraus. Es konnte nachgewiesen werden, dass regelmäßige körperliche Aktivität als Teil einer multifaktoriellen Intervention die Symptomatik von Patienten mit koronarer Herzkrankheit verbessert, eine Zunahme der myokardialen Perfusion...
The prevalence of obesity and diabetes is increasing rapidly. Coronary artery disease (CAD) represents the leading cause of death in diabetic patients. Diabetic patients are at a two- to fourfold risk of cardiovascular mortality compared with their nondiabetic counterparts. Silent myocardial ischemia more often occurs in diabetics than in nondiabetics. In general, the prevalence of silent CAD varies...
Herzinfarktkranke, die an einer Depression leiden, tragen ein erhöhtes Risiko, in den Folgejahren an einem erneuten Infarkt oder anderen Komplikationen der koronaren Herzkrankheit (KHK) zu sterben. Dass eine Depression, die bei 16–23% der KHK-Patienten auftritt, aber auch schon eine unterschwellige depressive Symptomatik einen unabhängigen prognostischen Faktor der KHK darstellt, konnte in mehreren...
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