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Question What is the influence of targeted medical therapies on disease control and survival in the adult patient with progressive glioblastoma? Targeted population This recommendation applies to adult patients with progressive glioblastoma RecommendationsLevel III Treatment with bevacizumab is recommended as it provides improved disease control compared to historical controls as...
Signal transducer and activator of transcription protein 3 (STAT3) is a regulator of central nervous system (CNS) development and a promising therapeutic target in human cancers. Activation of STAT3 promotes oncogenesis in a variety of tissues, but knowledge of its role in glioblastoma is still limited. Recent results indicate that STAT3 acts as a tumor suppressor or an oncogene depending upon the...
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