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Rutin is a flavonoid with various biological activities that are beneficial to human health. Trimethyltin is a toxic organotin compound, and rats injected with trimethyltin serve as a useful in vivo model for studying spatial memory impairment and neurodegeneration in the hippocampus. The protective effect of rutin against the trimethyltin-induced spatial memory impairment and hippocampal neuron damage...
Dizocilpine has been shown to be anticonvulsant in several experimental models of epilepsy. Nevertheless, 0.3 or 0.5 mg/kg intraperitoneal (i.p.) dizocilpine produced cortical spike-wave discharges (SWDs) in four of seven rats. The SWDs were accompanied by behavioral arrest, and also showed: a narrow range of induction times (around 25 min post-injection); hippocampal spikes closely correlated with...
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