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We have previously shown that intracerebroventricular administration of relatively low doses of β-endorphin suppresses basal levels of hepatic ODC activity as well as tissue ODC responsiveness to administered insulin in developing rats. Using Northern blotting analysis, the current studies examine whether these effects of CNS β-endorphin may be mediated by changes in ODC gene expression. Subcutaneous...
Our laboratory has previously shown that intracerebroventricular (i.c.v.) administration of β-endorphin suppresses brain and liver ornithine decarboxylase activity (ODC; a growth regulatory enzyme) in preweanling rats. This investigation examined, in 6-day-old rats, the relative participation of brain μ-, δ- and ε-opioid receptors in β-endorphin's ODC effects, by comparing tissue ODC responses to...
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