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The adaptive immune system of higher vertebrates is believed to have evolved to counter the ability of pathogens to avoid expulsion because their high rate of germline mutations. Vertebrates developed this adaptive immune response through the evolution of lymphocytes capable of somatic generation of a diverse repertoire of their antigenic receptors without the need to increase the frequency of germline...
Haematopoietic stem cells (HSCs) can be found in different locations of the developing vertebrate organism. Recent studies have detected functional changes in the haematopoietic system during ontogeny. Depending on the developmental stage, HSCs create different progeny, which express distinct marker genes. In addition, haematopoietic development is differentially affected by a variety of mutations...
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