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In the mammalian circadian clock located in the suprachiasmatic nucleus (SCN) glutamate mimics light-induced phase shifts through activating NMDA receptors (NMDAR). These phase shifts require concurrent activation of TrkB receptors by brain-derived neurotrophic factor (BDNF). tPA contributes to phase shifting by influencing mBDNF generation. tPA also binds to receptors, including LRP-1 and may modulate...
Alcohol abuse leads to cognitive defects, depression, and sleep disturbances. The connection between sleep and circadian disruptions led us to investigate ethanol's effect on the circadian clock. We demonstrated that acute ethanol blocks photic phase shifts in vivo and glutamatergic phase shifts in vitro. Ethanol exposure can lead to acute, rapid and/or chronic tolerance. We determined that the suprachiasmatic...
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