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Sequencing-by-synthesis technology takes us a step closer to the promises of personalized medicine by enabling affordable and fast DNA sequencing. Its accuracy, however, is fundamentally limited by the imperfections of the underlying biochemical processes and signal acquisition noise. In this paper, we focus on pyrosequencing systems, derive a mathematical model of the signal they acquire, and develop...
This paper presents the mean-square joint state filtering and parameter identification problem for uncertain linear stochastic systems with unknown parameters in both state and observation equations, where the unknown parameters are considered Wiener processes. The original problem is reduced to the filtering problem for an extended state vector that incorporates parameters as additional states. The...
The identification of the dynamic parameters of robot is based on the use of the inverse dynamic model which is linear with respect to the parameters. This model is sampled while the robot is tracking ldquoexcitingrdquo trajectories, in order to get an over determined linear system. The linear least squares solution of this system calculates the estimated parameters. The efficiency of this method...
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