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A synthesis of 4-amino-5-(2-thienyl)-1,2,4-triazol(4H)-3-ylthioacetanilides was developed, and these were chemically modified to produce 2-[5-(2′-thienyl-4-(1H-1-pyrrolyl)-4H-1,2,4-triazol-3-ylthio]acetanilidfes. The structures of the synthetic compounds were confirmed by 1H NMR spectroscopy. Predictions of pharmacological activity showed that the compounds synthesized here were likely to act on the...
Background Combretastatin A-4 (CA-4), which is an excellent antineoplastic agent, was isolated from Combretum caffrum. To date, structural modification studies of CA-4 have focused predominantly on the construction of new therapeutic agents for drug discovery. As a part of our ongoing work towards the modification of natural products, we have focused on the 3’-O-substituent groups in the B-ring of...
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