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Electrophysiological effects produced by selective activation of M3 cholinoreceptors were studied in isolated left atrium preparations from rat using the standard sharp glass microelectrode technique. The stimulation of M3 receptors was obtained by application of muscarinic agonist pilocarpine (10−5 M) in the presence of selective M2 antagonist methoctramine (10−7 M). Stimulation of M3 receptors induced...
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