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Glia over-stimulation associates with amyloid deposition contributing to the progression of central nervous system neurodegenerative disorders. Here we analyze the molecular mechanisms mediating microglia-dependent neurotoxicity induced by prion protein (PrP)90–231, an amyloidogenic polypeptide corresponding to the protease-resistant portion of the pathological prion protein scrapie (PrPSc). PrP90–231...
Prion diseases are characterised by the conversion of a normal glycoprotein, the prion protein, to an abnormal protease resistant form, which is suggested to be both the infectious agent and the cause of neuronal cell death in the disease. Death of the patient results from neurodegeneration. In this review, we present data arguing that neurodegeneration in prion diseases is a complex process, involving...
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