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Objective: Electric fields (EF) of approx. 0.2 V/m have been shown to be sufficiently strong to both modulate neuronal activity in the cerebral cortex and have measurable effects on cognitive performance. We hypothesized that the EF caused by the electrical activity of extracranial muscles during natural chewing may reach similar strength in the cerebral cortex and hence might act as an endogenous...
As epilepsy affects approximately one percent of the world population, electrical stimulation of the brain has recently shown potential for additive seizure control therapy. In this study we applied noninvasive transcranial focal stimulation (TFS) via concentric ring electrodes on the scalp of rats after inducing seizures with pentylenetetrazole (PTZ) to assess the effect of TFS on the electrographic...
We investigate thalamocortical interactions in the tetanus toxin and the cortical stimulation rat models of epilepsy. Using local field potential recordings from the cortex and the thalamus of the rat, the nonlinear regression index is calculated to create the direction index in order to study neurodynamics during seizures. Coarse time-scale analysis reveals that the cortex drives the thalamus for...
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