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The clinical use of high frequency alternating current (HFAC) to block nerve conduction in peripheral nerves is limited due to the large volley of nerve activity generated at the initiation of HFAC. This ldquoonset responserdquo must be characterized in order to determine if it is possible to eliminate it. In this study, preliminary experiments were conducted in an in-vivo animal model using counted...
The modulation of axonal excitability by high-frequency biphasic (HFB) electrical current was analyzed using a lumped-circuit model of the myelinated axon based on Schwarz-Reid-Bostock (SRB) equations. The results show that axonal excitability could be either increased or decreased by HFB current depending on the current intensity. The increase of axonal excitability is due to the high level of sodium...
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