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The first label-free LEAC biosensor immunoassay demonstration is reported. CMOS chips with integrated photoconductor arrays detected 150 kDa tuberculosis related antibodies and 18 kDa protein antigens. The limit of detection for thickness change was 120 pm.
A LEAC biosensor on a CMOS chip with integrated buried detector array demonstrated 50% photocurrent modulation in response to a patterned nanoscale 2.5 nm thick bovine serum albumin (BSA) film.
Patterned nanoscale organic films including photoresist and bovine serum albumin locally modulate the evanescent field distribution of a SiNx core waveguide and are sensed with an integrated photodetector array on a CMOS chip.
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