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Today single cell research is a great interest to analyze cell to cell or cell to environment behavior with their intracellular compounds, where bulk measurement can provide average value. To deliver biomolecules precise and localized way into single living cell with high transfection rate and high cell viability is a challenging and promisible task for biological and therapeutic research. In this...
Despite the significant research in electroporation, high electric field was applied to the whole cells resulted in permeabilizing the membrane of millions of cells without reversibility [1]. To deliver biomolecules through the specific region of the cell membrane with high cell viability and high transfection rate is important for various biological and therapeutic applications.This report presents...
In this paper we demonstrate the adoption of both electrophoresis (EP) and dielectrophoretic (DEP) forces to control the movement of a single DNA and stretch this DNA as a stretched bridge across two Al metal electrodes at specific positions. The moving speed of the single DNA molecule can also be manipulated from 0.615 to 2.285μm/s inside a nano-pore region by DEP controlling the opening size of...
Advances in microfabrication have introduced new possibilities for automated, high-throughput biomedical investigations and analyses. Physical effects such as dielectrophoresis and electroporation can be used to manipulate particles in solution to coordinate a sequence of bioanalytical processing steps. Dielectrophoresis is accomplished with non-uniform electric fields that can polarize particles...
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