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Cortical development involves the structuring of network features by genetically programmed molecular signaling pathways. Additionally, spontaneous ion channel activity refines neuronal connections. We examine Ca2+ fluctuations in the first postnatal week of normal mouse neocortex and that expressing knockout of the transcription factor T‐brain‐1 (Tbr1): a signaling molecule in cortical patterning...
Spontaneous waves of activity that propagate across large structures during specific developmental stages play central roles in CNS development. To understand the genesis and functions of these waves, it is critical to understand the spatial and temporal patterns of their propagation. We recently reported that spontaneous waves in the neonatal cerebral cortex originate from a ventrolateral pacemaker...
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