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Children exposed to valproate monotherapy in utero were evaluated with respect to neurological functioning, behavior, and additional educational needs, and the results were compared with those for age- and gender-matched controls exposed to carbamazepine and children with no prenatal exposure to antiepileptic drugs. We identified from the community-based pregnancy registry of Kuopio University Hospital...
Valproate therapy has been associated with significant decreases in serum-free carnitine plasma concentrations. This double-blind, placebo-controlled cross-over study investigated the usefulness of carnitine supplementation in affecting perceived energy levels in a group of adolescents with epilepsy treated with valproate monotherapy. Eleven males and eight females received a randomized placebo phase...
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