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Metastatic breast cancer is an incurable disease and the main goals of treatment are prolongation of survival and preservation/improvement of quality of life. Thus the main philosophy of treatment should be to use the least toxic methods, as long as they provide sufficient disease control. In ER-positive tumours this can be in many cases achieved by endocrine therapy; in HER2-positive cancers efficacy...
Adjuvant systemic therapies for breast cancer have led to a significant reduction in the risk of relapse and improvement in overall survival. However, a substantial proportion of breast cancer patients still ultimately experience relapse with metastatic disease. Here we review recent progress in trials of systemic therapies, including endocrine therapy, chemotherapy and targeted therapies for breast...
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